How long does it take to drive from nashville tennessee to cincinnati ohio? -

about 6 hours.Nashville to Louisville to Cincinnati.I-65 - I-265 - I-71 - I-75You will cross the time zone (eastern/central) at the Hart/Hardin county line, just south of E-Town

it will take about 4 hours 30 minutes to cover the approximately 280 miles - most of the drive will be on I-71 and I-264

5 hours- I live in Cincinnati