How long would it take to drive from Commack, NY to Manhattan? -

If you mean long islan about hour and a half if you leave at 3am weekdays. If you leave weekdays at 6am till well anytime in the day about 3 hrs Take the LIRR

all i know is, from the center of the island to the city( if you leave at like 3am) it will take 45-60 minutes.