I-15 is the way to go... there is no way that is more direct, or any faster. The only exception might be IF there were a huge traffic problem... then you can take I-40 to Needles area, then 95 up to Vegas. But that adds 100 miles to the trip, and should only be used if I-15 is blocked for some reason.
A dune buggy?You couldn t go in much straighter a line than I-15.A back-way would be going around Blythe way.
Helicopter or small plane.