I would take the E train on W42 up to 53rd and 5ave.Than your going to have to walk to 53rd and W11ave(Go towards 53rd, 6th ave) MoMA is on 53rd and W11th
Just to clarify, the address of MoMa is 11 West 53rd Street, which is between 5th and 6th Avenues, nowhere near 11th Avenue...What part of 42nd Street? If you re on the east side, I d say just walk it on a nice day, it s a nice walk.If you re on the west side, I still say walk it, but a ride on an uptown/Queens-bound E train (on 8th Avenue/Times Square) or an uptown/Queens-bound V train (on 6th Avenue/Bryant Park) will bring you to 5th Avenue/53rd Street. Go upstairs and you re there.EDIT: I stand by my correct answer despite the thumbs-down.
Best way really is to walk. It is about a fifteen minute walk and any transportation that you take will eat up at least that much time. Just walk uptown eleven blocks to 53rd street. It is located between fifth and sixth avenues. FGree admission can be had on Fridays after four courteousy of Target s, but the lines can be long.
Walk a block west to the Port Authority Bus Terminal and take the Queens-bound (eastbound) E train (Blue Line on the subway map) from the bus terminal to 5th Avenue and 53rd Street.MoMa is located a short walk from the subway station.I hope this infomration is very helpful.Good luckNative New Yorker