On Thanksgiving night, it should be alright.On Wednesday is when the freeways turn to Hell!!
I m driving to Rancho Mirage from L.A. on Thanksgiving also and while it s been rather light in the past, I m leaving early just in case. I m guessing you should expect to spend no more than 2 1/2 hours driving...
On Thursday it should be light.
Not as much as on Wednesday.