I would suggest just getting on I-90 and going West. That highway goes all the way to Seattle, in more or less a straight line. The interstate will be plowed better than the minor roads, and if you wanted to go farther South to avoid snow, you d add way, way too much distance to your trip.Or you could just fly...much faster, and cheaper overall if you include the cost of wear and tear on your vehicle and if you re going alone.
Check google maps and use their direction finder.
I-90 is a straight shot.