It depends on your route, time of day, and traffic. Most direct route is 101 east, staying straight even when the numbers change to 134, then 210. Take the 210 to 15 north, which goes to Victorville. It s 173 miles, which would take about 3 hours with no traffic. But traffic on the 101 (in the SF Valley) or 134/210 (Burbank, Glendale, Pasadena) can be very bad, depending on the time of day.Allow at least an hour for traffic unless you are going early morning or late at night, so figure 4 hours, give or take.
If you drive it would take about 2hrs and 45min - 3hrs and 20 min
how by car by boat ? by bus by airplane?you dont say so we can answer sorry!