I ve lived in many areas of Florida, what do you like? City living or rural living. Do you need to find work or are you retired. Is cost a problem or are you open to any price. Florida is a varied place and you can have almost any type of place to live. I am partial to central Fl, around the Ocala area. Close to highways to be able to travel, but out in the country style living. If you like horses that is the place to be.
This is a very individual choice. Personally, I loved living in Panama City Beach where I could sit on my deck in the evening and watch the sunsets over the Gulf of Mexico. I also like the area around Tampa. Other people will have different opinions. What might be best for you depends on your personal preferences.